62. GLP-1s: What They Do, What They Don’t, and What You Need to Know

August 19, 2026

GLP-1 medications have become one of the biggest conversations in weight loss, and Lisa believes the discussion needs more nuance than simply deciding whether they are “good” or “bad.”

In this episode, Lisa breaks down what GLP-1 actually means, how the hormone works naturally inside the body, and why medications such as Ozempic, Wegovy, Mounjaro, and others can reduce appetite, slow stomach emptying, and support blood sugar regulation. She also walks through common side effects, including nausea, constipation, fatigue, digestive changes, and loss of lean muscle mass.

But this conversation goes beyond medication. Lisa explains how protein, fiber, exercise, insulin sensitivity, hunger hormones, and gut health all play a role in appetite and body composition. She also challenges listeners to ask a deeper question: what led to the weight gain, fatigue, cravings, or metabolic struggles in the first place?

This episode is not about shaming anyone for using a GLP-1. It is about understanding your options, becoming an active participant in your health, and recognizing that sustainable change still requires attention to the habits, food, and lifestyle supporting your body every day.

In this episode, Lisa explores:

  • What GLP-1 is and how your body naturally produces it
  • How GLP-1 medications affect appetite, digestion, and blood sugar
  • Common side effects and concerns around muscle loss and digestive health
  • Why protein, fiber, movement, and insulin sensitivity still matter
  • The connection between gut health, hunger hormones, and sustainable weight management

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Welcome to Let’s Talk Sh*t—the podcast that tells you what no one else will.

I’m Lisa Garrett, your no-BS gut health expert, here to drop truth bombs on energy, confidence, and feeling GOOD in your body again.

We’re talking real food, real life, and real solutions—so you can ditch the bloat, brain fog, and burnout… and step into a body that actually works for you.

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